In the News & Publications
Endoscopic sleeve gastroplasty gains global focus after DDW 2026
Dr. Noppachai Siranart's commentary in The Nation on how endoscopic sleeve gastroplasty — delivering 18–25% weight loss without major surgery — fills the gap between medication and bariatric surgery.
GAE offers non-surgical relief for osteoarthritis knee pain
Dr. Noppachai Siranart's commentary in The Nation on Genicular Artery Embolization (GAE) — a minimally invasive procedure that blocks abnormal blood vessels to relieve chronic knee osteoarthritis without major surgery.
Younify Clinic Bangkok: Helping Expats Stay Active, Healthy and Independent for Longer
Expats in Bangkok features YOUNIFY Clinic — a Bangkok provider of minimally invasive treatments for weight management, knee pain, and chronic conditions, with personalized care for international patients.
A new option: SGB — an injection that resets the autonomic nerve ganglion to relieve insomnia and chronic stress
A new medical trend: Stellate Ganglion Block (SGB) — an injection that resets the autonomic nerve ganglion in the neck, a new option to relieve insomnia and accumulated stress.
Doctors reveal a new trend: incision-free “endoscopic stomach tightening” — an answer for medication non-responders and yo-yo dieters
A new trend from the DDW 2026 world stage: Endoscopic Sleeve Gastroplasty (ESG), a modern option against obesity with 18–25% weight loss — no major surgery required.
A new option for knee osteoarthritis: “GAE” breaks the pain cycle without surgery
An in-depth look at GAE — embolisation of abnormal blood vessels — a new specialist-led option for knee osteoarthritis: safe, non-surgical, with fast recovery.
The end of major surgery? A new global obesity-care trend from the DDW 2026 stage
Dr. Noppachai Siranart introduces Endoscopic Sleeve Gastroplasty (ESG) — an incision-free weight-loss option with less pain and a fast recovery. Featured on the Nation Online page.
The “weight-loss injection pen” (GLP-1) debate — to inject or not?
A widely shared analysis of the weight-loss injection pen debate — worth reading before deciding whether GLP-1 medication is right for you. Featured on the Drama-addict page.
Our Health Articles
ESG in Bangkok: Endoscopic Sleeve Gastroplasty for Non-Surgical Weight Loss
ESG in Bangkok is non-surgical weight loss via endoscopic sleeve gastroplasty. Learn how it works, who qualifies, expected results and recovery at YOUNIFY Clinic.
GAE Knee Treatment in Thailand: A Non-Surgical Option for Knee Osteoarthritis
GAE knee treatment (Genicular Artery Embolization) in Bangkok — a non-surgical option to ease knee osteoarthritis pain, same-day discharge for most patients. Consult our medical team.
Weight Regain After Sleeve: Revision Options
A patient-friendly summary of Dr. Noppachai Siranart's research on recurrent weight gain after sleeve gastrectomy and how endoscopic sleeve-in-sleeve compares with surgical revision.
GLP-1 Before Endoscopy: Stop or Continue?
A patient-friendly summary of Dr. Noppachai Siranart's research on GLP-1 receptor agonists, gastric emptying, and upper endoscopy safety.
Knee Pain & Osteoarthritis
Knee Pain Treatment: Non-Surgical Options
A detailed guide to knee pain: common causes, warning signs, physical therapy, injections, PRP, and GAE as a non-surgical option for selected patients.
Knee Pain Walking: Causes and Warning Signs
Knee pain during walking, stairs, or longer activity may relate to osteoarthritis, muscle imbalance, meniscus problems, or overuse.
Inner Knee Pain: Causes and Treatment
Inner knee pain may involve medial compartment osteoarthritis, medial meniscus injury, MCL irritation, or tendons and bursae around the knee.
Knee Osteoarthritis: Symptoms, Stages, and Options Before Surgery
A clear guide to knee osteoarthritis, from symptoms and staging to non-surgical care, injections, GAE, and when surgery may be considered.
How to Treat Knee Osteoarthritis Without Surgery: Your Options and GAE
The non-surgical options for knee osteoarthritis — from weight loss and exercise to medication and injections — plus why the evidence for PRP and growth factors remains unclear, and a look at GAE (genicular artery embolization), a newer non-surgical option for suitable patients.
What Causes Knee Pain? Common Causes and How to Spot Osteoarthritis
The common causes of knee pain — from osteoarthritis, ligament and meniscus injury, tendinitis, and overuse to excess weight, inflammatory arthritis, and referred pain — plus how to tell if it is osteoarthritis, and care options from the basics to GAE for chronic pain.
Early Symptoms of Knee Osteoarthritis: 5 Signs Not to Ignore
The early symptoms of knee osteoarthritis — brief morning stiffness under 30 minutes, pain on stairs or after activity, mild swelling, grinding sounds, and reduced range of motion — plus why acting early helps, and the GAE option for chronic pain.
Stages of Knee Osteoarthritis: Grades 1–4 and Care at Each Stage
Understanding the stages of knee osteoarthritis by the Kellgren–Lawrence system, grades 1 to 4 — what each grade means, how to manage it, and why GAE suits the mid stages of chronic pain that has not responded to the basics but is not ready for a replacement.
Knee Crepitus and Clicking: Is It Dangerous? When to Worry
Is a cracking or clicking knee normal or dangerous? Understand why painless knee sounds are usually harmless, but sounds with pain, swelling, or locking deserve caution — plus what it means in osteoarthritis, and the GAE option for chronic pain.
When to See a Doctor for Knee Pain: Red Flags and Timing
Knowing when knee pain needs a doctor — from red flags like severe swelling, deformity, fever, inability to bear weight, or a locked knee, to chronic pain lasting beyond 1–2 months that self-care hasn't helped — plus what an assessment gives you and the GAE option.
Does Glucosamine Work for Knees? What the Evidence Says
Do glucosamine and chondroitin supplements really help knee osteoarthritis? What the evidence shows, whether they are safe to try, why they are not a substitute for weight loss and exercise, and how GAE offers a non-surgical option for chronic knee pain.
Hyaluronic Acid Knee Injections: Do They Work and How Long?
Do hyaluronic acid (viscosupplement) knee injections really work, and how long does the effect last? What the evidence and guidelines say, what to expect, and how GAE offers a non-surgical option for chronic knee pain.
Do PRP and Stem Cell Injections Help Knee Osteoarthritis?
The truth about PRP, stem cell, and growth factor injections for knee osteoarthritis — why the evidence is unclear and inconsistent, why they are not standard care, and why they are often costly and out-of-pocket. Plus better-evidenced options and non-surgical GAE.
Are Steroid Knee Injections Safe? How Often Is Too Often?
Are cortisone/steroid knee injections safe, how much do they help, and how often can you have them? What to know about short-term relief, frequency limits, and concerns about cartilage with repeated use — plus GAE as a non-surgical option for chronic knee pain.
Which Painkillers Are Safe for Knee Osteoarthritis?
Which painkillers are safest for knee osteoarthritis? Why topical NSAIDs are first-line, how to use oral NSAIDs safely for your kidneys, stomach, and heart, how much paracetamol helps, and why to avoid long-term opioids — plus GAE as a non-surgical option.
The Best and Worst Exercises for Knee Osteoarthritis
The best exercises for knee osteoarthritis — quadriceps and hip strengthening, cycling, swimming, walking, and tai chi — plus the moves to avoid or modify, and guidance for people with chronic pain who may consider GAE, a non-surgical knee artery embolization.
Can I Walk, Run, and Climb Stairs with Knee Osteoarthritis?
Can you still walk, run, and climb stairs with knee osteoarthritis? Walking is beneficial, running is case-by-case, and stairs have smart strategies — plus GAE, a non-surgical knee artery embolization for people with chronic pain.
Heat or Ice for Knee Pain: Which Should You Use?
Should you use heat or ice for knee pain? Ice suits acute pain, swelling, and after activity, while heat suits stiffness and warming up before activity — plus how to apply both safely, and GAE for chronic pain.
Does Losing Weight Really Reduce Knee Pain?
The truth about weight and knee pain: every step loads the knee with about 3 to 4 times your body weight, so losing 1 kg cuts roughly 4 kg of knee load per step, and even a 5 to 10 percent loss meaningfully eases pain — plus the clinic's weight program and GAE.
Foods and Supplements for Knee Joints: What Actually Helps
The truth about foods and supplements for knee joints: an anti-inflammatory Mediterranean diet, omega-3, vitamin D, and a healthy weight genuinely help, while popular supplements have limited evidence — plus GAE for chronic knee pain.
When Do I Need Knee Surgery? Signs and Options Before a Replacement
Understand when knee osteoarthritis truly calls for a knee replacement, the signs and stages that count as real indications, why surgery is not the first choice, and how GAE (genicular artery embolization) may delay or avoid surgery in suitable patients.
How Long Does a Knee Replacement Last? Recovery and Options Before Surgery
How long an artificial knee lasts, how many weeks to months recovery takes, why revision surgery is harder than the first operation, and why delaying surgery with non-surgical options like GAE makes sense — especially for younger patients.
Can Knee Osteoarthritis Be Cured? The Truth and How to Manage It
An honest answer to whether knee osteoarthritis can be cured or cartilage regrown, the truth about PRP and stem cells, how to control pain and restore function, and how GAE offers a non-surgical option focused on easing pain.
What Happens If Knee Osteoarthritis Is Left Untreated?
What happens if knee osteoarthritis is left untreated — from worsening pain and stiffness to muscle weakening, difficulty walking, and eventual deformity — why acting early helps, and how GAE offers a non-surgical option.
Pain Medicine
Chronic Neck Pain Treatment: Non-Surgical Options That Come Before Surgery
Chronic neck pain that won't go away? Learn the common causes, red-flag symptoms, and a step-by-step, non-surgical treatment path from YOUNIFY's medical team in Silom, Bangkok.
Radiofrequency Ablation for Neck Pain: What Medial Branch Block and RFA Are, and How Much They Help
How radiofrequency ablation (RFA) and medial branch block relieve chronic facet-joint neck pain — needle-based, image-guided, no surgery, same-day. Explained by YOUNIFY's medical team.
Chronic Back Pain and Pain Radiating to the Leg: How to Treat It, Step by Step
What causes chronic back pain and pain radiating to the leg, the red flags that need urgent review, and a stepwise path from non-surgical care to surgery — by the YOUNIFY Clinic medical team, Silom, Bangkok.
Epidural Steroid Injection (ESI) for Back Pain That Radiates Down the Leg
What is an epidural steroid injection (ESI) for back pain that radiates down the leg? How it works, who it suits, how long relief lasts — explained by the YOUNIFY medical team in Silom, Bangkok.
Neck Pain Radiating to Arm and Arm Numbness: Signs of Cervical Radiculopathy
Neck pain radiating to the arm with numbness or weakness may signal cervical radiculopathy from a compressed nerve root. Learn causes, warning signs, diagnosis and treatment options.
Office Syndrome: How to Relieve Neck, Shoulder and Upper-Back Pain
Office syndrome neck and shoulder pain (tech neck): what causes it, 5 practical stretches, ergonomic desk setup, warning signs it may be more, and when to see a doctor.
Cervical Herniated Disc: Symptoms, Causes, and Treatment Options
What a cervical herniated disc is, why it causes neck pain radiating down the arm with numbness, how MRI confirms it, and non-surgical to surgical options — explained by the YOUNIFY Clinic medical team, Silom, Bangkok.
Sciatica (Sciatic Nerve Pain): What It Is and How It Is Treated
What sciatica (sciatic nerve pain) is, its symptoms, causes from herniated disc and piriformis muscle, and treatment options from conservative care to image-guided injections by our medical team.
Lower Back Pain from Lifting or Sitting: Prevention and Early Care
Why lifting heavy or sitting too long triggers lower back pain, how to lift safely, 5 core exercises, ergonomic desk setup, and the red flags to see a doctor — from the YOUNIFY medical team, Bangkok.
Lumbar Herniated Disc: Symptoms and Treatment Options
What a lumbar herniated (slipped) disc is, its symptoms, causes and risk factors, MRI diagnosis, and non-surgical versus surgical treatment options, including image-guided injections, by our medical team.
Weight Loss & Stomach
Weight Loss Without Surgery: Why ESG Is Gaining Ground Over Stomach Surgery
A new global study co-authored by Dr. Noppachai Siranart compared 7 weight-loss procedures in over 61,000 patients. Endoscopic sleeve gastroplasty (ESG) improved obesity-related conditions well — and carried a markedly lower risk of new acid reflux than stomach surgery — all without a major operation.
GLP-1 and MASH Fatty Liver
A clear summary of Dr. Noppachai Siranart's meta-analysis on GLP-1 receptor agonists and biopsy-confirmed MASH.
How to Lose Weight Fast Without the Rebound: The Safe, Effective Way
How fast can you safely lose weight? We cut through the myths on calorie deficit, explain why crash diets rebound, and cover the medical options — lifestyle intervention paired with GLP-1 medication and endoscopic sleeve gastroplasty (ESG) — for people who have tried everything.
How to Lose Belly Fat: What Actually Works, Not Spot Reduction
Can you target belly fat directly? We debunk the spot-reduction myth, explain why visceral fat is a real health risk, and cover what actually works — a calorie deficit, protein and fibre, less sugar and alcohol, sleep, and training — plus the medical options at YOUNIFY when effort isn't enough.
What Is a Calorie Deficit and How Many Calories Should I Eat? A TDEE Guide
What is a calorie deficit and how many calories should you eat to lose weight? Learn energy balance, how to estimate your TDEE from BMR × activity, how to set a sensible 500–750 calorie deficit, and how to track and adjust — plus the medical options at YOUNIFY when self-directed deficits stall.
Can You Lose Weight Without Exercise? The Truth and Your Options
Can you lose weight without exercise? Yes — weight loss comes mostly from diet and a calorie deficit, though exercise helps with maintenance and health. Plus the medical options like GLP-1 and ESG at YOUNIFY for those who can't lose with diet alone.
Do GLP-1 Weight-Loss Injections (Ozempic) Really Work? Safety and Cost
An honest look at GLP-1 injections like Ozempic/Wegovy and Mounjaro — how well they work in the trials, whether they are safe, what they cost, and when to use them under medical supervision alongside lifestyle change and ESG for lasting results.
GLP-1 (Ozempic) Weight-Loss Side Effects: What They Are and How to Manage Them
The side effects of GLP-1 weight-loss injections like Ozempic/Wegovy and Mounjaro — from common gut symptoms to gallbladder issues, dehydration, and muscle loss — plus how to manage them and why medical supervision matters.
Will You Regain Weight After Stopping GLP-1? And How to Keep It Off
After stopping GLP-1 injections like Ozempic/Wegovy, weight commonly returns because obesity is chronic and appetite rebounds. This article explains why, and covers the options for holding results long term — continued medication, tapering with lifestyle change, or a durable option like ESG.
Keto Diet Explained: What Is Keto and What Can You Eat?
A plain-language guide to the very-low-carb ketogenic diet — ketosis, foods you can eat and should avoid, the pros (appetite, quick water-weight loss) and cons (sustainability, side effects), and why keto still works through a calorie deficit.
How to Lose Weight Without the Yo-Yo: Avoiding Weight Regain
The science of keeping weight off after you lose it — preserving muscle, enough protein, self-monitoring, gradual loss, and habit change — plus the medical options for people who keep regaining despite real effort.
International Publications
Improvement of Obesity-Related Comorbidities After Bariatric Procedures: A Network Meta-Analysis of Endoscopic Versus Surgical Interventions
OAGB, SASI, SADI, and ESG demonstrate superior efficacy in improving obesity-related comorbidities and GERD outcomes, supporting their consideration as leading options in individualized bariatric care.
Visual and Neurological Outcomes Following Glucagon-Like Peptide-1 Receptor Agonist Therapy and Bariatric Surgery in Idiopathic Intracranial Hypertension: A Network Meta-Analysis
Adjunctive GLP-1RA therapy may be associated with weight loss and improved clinical/ophthalmic outcomes in IIH relative to conventional care, with a signal for worse visual fields at certain time points.
Endoscopic Management for Non-Variceal Upper Gastrointestinal Bleeding: A Network Meta-Analysis of Randomized Controlled Trials and Cost-Effectiveness Analyses of 2 Health Care Systems
OTSC was superior to HP and ST in efficacy and cost-effectiveness, favoring its use as a first-line endoscopic hemostasis intervention for NVGIB.
Effect of glucagon-like peptide-1 receptor agonists on histologic MASH: A meta-analysis of randomized controlled trials
In patients with noncirrhotic MASH, GLP-1RAs appear to be associated with both MASH resolution without fibrosis worsening and ≥1-stage fibrosis regression without MASH worsening.
Endoscopic versus surgical management of recurrent weight gain following sleeve gastrectomy
Endoscopic revision of SG appears to be associated with similar weight loss compared with surgical revision or conversion to Roux-en-Y gastric bypass, with a better safety profile.
Can GLP-1 agonists be used safely in inflammatory bowel disease? A meta-analysis
GLP-1RAs appear to be safe and effective in patients with IBD.
Glucagon-like peptide-1 receptor agonists and upper endoscopy: a real-world experience
Continuation of GLP-1RAs did not appear to be associated with an increased incidence of residual gastric contents, early procedural termination, or aspiration events.
Leadless Pacemaker in Bradyarrhythmia After Transcatheter Aortic Valve Replacement: A Meta-Analysis
LPM could serve as a first-line pacing strategy in bradyarrhythmia post-TAVR due to its safer profile with comparable efficacy and feasibility to TPM.
Slow-inactivated sodium channels as a therapeutic target in trigeminal neuralgia: evidence from a systematic review and meta-analysis of lacosamide
Lacosamide (LCM) has shown favorable outcomes in some patients with trigeminal neuralgia (TN) and may serve as an alternative therapy, particularly those refractory to or intolerant of first-line agents, and intravenous LCM may be useful for acute exacerbations.
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